Can theory help us understand cancer metastasis?

Herbert Levine
Center for Theoretical Biological
Physics, Rice University


In order to spread from the primary tumor to distant sites, cancer cells must undergo a coordinated change in their phenotypic properties referred to as the "epithelial-to-mesenchymal" transition. We have studied the nonlinear genetic circuits that are responsible for this cellular decision-making progress and propose that the transition actually goes through a series of intermediate states. At the same time, we have formulated motility models that allow for the correlation of state of this network and the cell's biophysical capabilities. Hopefully, these efforts will help us better understand the transition to metastatic disease and possible treatments thereof.